GM-CSF Nitration Is a New Driver of Myeloid Suppressor Cell Activity in Tumors

GM-CSF Nitration Is a New Driver of Myeloid Suppressor Cell Activity in Tumors

Blog Article

Reactive oxygen species, including RNS, contribute to the control of multiple immune cell functions within the tumor microenvironment (TME).Tumor-infiltrating myeloid cells (TIMs) represent the archetype of tolerogenic cells that actively contribute to dismantle effective immunity against cancer.TIMs inhibit T cell functions and promote tumor progression by several mechanisms Double Oven Range including the amplification of the oxidative/nitrosative stress within the TME.

In tumors, TIM expansion and differentiation is regulated by the granulocyte-macrophage colony-stimulating factor (GM-CSF), which is produced by cancer and immune cells.Nevertheless, the role of GM-CSF in tumors has not yet been fully elucidated.In this study, we show that GM-CSF activity is significantly affected by RNS-triggered Titanium post-translational modifications.

The nitration of a single tryptophan residue in the sequence of GM-CSF nourishes the expansion of highly immunosuppressive myeloid subsets in tumor-bearing hosts.Importantly, tumors from colorectal cancer patients express higher levels of nitrated tryptophan compared to non-neoplastic tissues.Collectively, our data identify a novel and selective target that can be exploited to remodel the TME and foster protective immunity against cancer.